CELEBREX (celecoxib)

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Celebrex is thus expected to be the first in a new class of painkillers and anti inflammatory drugs called "cox-2 inhibitors" to hit the U.S. market.

For treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis, headache, arthrosis, pain bones. Usual dosage adults  is 200-400 mg taken in two divided doses. A 200 mg dose can be given once daily in osteoarthritis.

Wall Street views Celebrex as the next potential blockbuster drug, because of hope that it will cause fewer ulcers, stomach bleeding and other gastrointestinal side effects commonly caused by today's most popular painkillers. Analysts predict that tens of millions of people will take cox-2 inhibitors to relieve a variety of kinds of pain.

Millions of people now depend on aspirin, ibuprofen, naproxen and a host of other pills called "non-steroidal anti  inflammatory drugs," or NSAIDs. They're used for arthritis, everyday aches, recovery from surgery and a myriad of other pains. Many are available without a prescription; others come in higher-dose prescription-only strengths.

But NSAIDs can cause ulcers, stomach bleeding and other gastrointestinal side effects, especially in long-term users. NSAIDs are
blamed for hospitalizing 107,000 Americans every year, and killing 16,500.

In 1990, scientists announced the reason. NSAIDs target an enzyme called cyclooxegenase that is responsible for much inflammation behind pain. But it turned out there are two types of this enzyme. Cox-2 was behind the inflammation, while cox-1 actually protects the stomach lining. Unfortunately, NSAIDs hit both.

How to order this Searle wonderful new drug against pains, headache, arthritis, arthrosis, bones pain, menstrual discomfort,  low price ? This is also the fruit of our searches of the suppliers of the whole world!

See also Vioxx.

The theory was that if scientists could develop a more specific drug that targeted just cox-2, it would alleviate pain and inflammation while not bothering the stomach. Half a dozen companies began racing to develop a better NSAID.

Searle's Celebrex, known chemically as celecoxib, is the first under FDA scrutiny. In studies of about 13,000 patients, it appeared to work almost as well as prescription-strength naproxen in patients with osteoarthritis. In rheumatoid arthritis sufferers, it appeared to work almost as well as another popular NSAID, diclofenac.

But even if Celebrex isn't better than other painkillers, experts theorized it still would sell if proved safer. So Searle gave 4,700 endoscopies -- snaking a tube into patients' stomachs to see if ulcers were forming even before they experienced symptoms. Some 25 percent to 40 percent of patients taking ibuprofen or naproxen showed these mini-ulcers, vs. 5 percent to 10 percent of Celebrex patients.

Celebrex is the new FDA-approved wonderdrug which is used to treat osteoarthritis and rheumatoid arthritis.
Simply amazing, it reduces pain, tenderness, stiffness and swelling in affected joints ... so you can live a younger, healthier and much more active life.

Celecoxib (Celebrex) is one of the first designer drugs to be marketed, and its development is typical of the advances that modern molecular biology is bringing to the understanding and treatment of diseases.

Most of the medicines that we take for inflammation and pain are members of a class of drugs known as nonsteroidal anti  inflammatory drugs, NSAIDs. These include aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), naproxen (Naprosyn) and many others.
For many years these drugs have been very commonly used to treat minor aches and pains, headache, and various chronic conditions such as osteoarthritis and rheumatoid arthritis. These drugs all interfere with the formation of a family of natural chemicals found in many tissues called prostaglandins, which are involved in the development of inflammation and pain.

It has been known for a long time that prostaglandins are important in many normal processes in our bodies, for example in maintaining a normal lining of the stomach, and that interfering with them would produce side effects. In the case of the stomach these can be ulcers or the inflammation known as gastritis. It has been shown many times that people taking these drugs have a high incidence of stomach ulcerations, even if they have no pain. These can lead to life-threatening bleeding, and NSAIDs are implicated in most such bleeding cases that require hospital admission.

For a long time it was thought that the interference with the protective functions of prostaglandins could not be separated from the beneficial effects against inflammation and pain, but in recent years the identification and cloning of two genes which control
prostaglandins has made it possible to separate the beneficial effects from most of the bad side effects. These genes have been identified as COX-1 and COX-2, and celecoxib was synthesized to interfere only with the action of COX-2. It is therefore designated a COX-2 NSAID. All the previous NSAIDs interfered with both COX-1 and COX-2.

Studies have shown that celecoxib causes many fewer side effects in the stomach, almost at the low level of the placebo used in the studies. It also does not interfere with the proper functioning of our blood platelets, which the other NSAIDs do, and will therefore probably be shown to be safe in cases where bleeding is a problem, or immediately prior to surgery, when most surgeons make their patients stop any NSAIDs they may be taking. Other less common NSAID side effects such as interference with kidney function and confusion have not yet been fully studied.

Celecoxib (a new aspirin?) has been shown to be as effective as the earlier NSAIDs in the treatment of mild to moderate pain, and chronic inflammatory conditions such as rheumatoid arthritis, arthrosis, pain bones.