The HairPrime ® Program is aimed at providing the best overall environment for hair to grow. Even the shampoo is carefully formulated to avoid ingredients which are found in many other shampoos and which we have determined as harmful to the scalp and healthy hair growth. The active ingredients contained in HairPrime ® Herbal Lotion and Herbal Scalp Primer address the effects of environmental factors on the scalp and DHT (the main cause of male pattern baldness). If HairPrime's ingredients are effective, DHT doesn't have as much of an impact, and thus the follicle's potential for nurturing hair growth is improved . Through the regular use of HairPrime ® your body receives a constant supply of nutrients and healthy hair factors. We have found that most people need to use HairPrime ® for about 12 months before substantive results are experienced and confirmed. HairPrime ® aims to maintain a healthy environment for hair follicles and restore the normal growth cycles of hair to keep your hair growing longer and thicker until it matures (i.e. "The Conversion To Terminal Hair" presented at the American Academy of Dermatology Conference in New Orleans, March, 1999)

DOUBLE BLIND HAIR GROWTH STUDY - THE EFFECTS OF HairPrime ®

These are the results of the latest independent, clinical, double-blind study conducted by Dr. Joseph Greenberg, a Board Certified Dermatologist and Clinical Professor of Dermatology at U.C.S.F. This study was presented at the Annual Conference of the American Academy of Dermatology (Feb. 1995), and Published in the prestigious Journal of Dermatological Treatment (Sept. 1996), and the Townsend Letter (Nov. 1996).

The study shows that HairPrime ® helped to promote thicker, healthier hair growth for 90% of the subjects in the active group. Accompanying photographs may be viewed here. Full text with tables and graphs will be faxed or mailed upon request.

 Average Percentage Change Between HairPrime ® & Placebo Groups

TABLE 1	Average % Change HairPrime ® Group	Average % Change Placebo Group
Total Hair Count	77.4 %	0 %
Terminal Hair Count	169 %	35 %

 

Introduction:

Twenty-four healthy male subjects with Stage III-IV androgenetic alopecia were enrolled in a randomized, double-blind, parallel vehicle-controlled study to confirm the effectiveness and safety of a topically applied, standardized 7.5% herbal preparation (HairPrime ®) cream used once daily in the treatment of androgenetic alopecia--the most common cause of hair loss, affecting one third of both men and women.

In preliminary studies HairPrime ® produced encouraging results as a hair growth agent. In one pilot study, all 18 subjects showed increased hair counts, averaging 119%. The investigator observed a very high percentage (50-100%) of conversion from vellus to terminal hair, and hair remelanization (50-100%).

HairPrime ® cream has also been evaluated for the treatment of scalp seborrhea and psoriasis. The results of this study confirm the safety and effectiveness of the cream formulation and should be of interest to both general practitioners and dermatologists who treat patients with androgenetic alopecia.

 Materials and Method

Study design and medications:

HairPrime ® is a patented, standardized 7.5% herbal extract in a cream base vehicle. The extract is standardized by replicative methods, including standardization against specific compounds which appear naturally in the extract.

A double-blind, placebo-controlled trial was conducted to compare the effect of HairPrime ® on hair growth in males with androgenetic alopecia against its placebo vehicle. The subjects were given either HairPrime ® or a placebo of vehicle only. Both the active and the placebo groups were each randomly assigned four subjects with excessive hair loss. Patients applied the cream to the scalp daily, at approximately 24 hour intervals, for 40 weeks and were seen in the clinic for efficacy and evaluation every 4 weeks throughout the study. Subjects had their hair collected six times at eight week intervals (eight weeks at baseline and an additional forty weeks of follow-up).

Twenty-four healthy male subjects under the age of 55 were selected for the study. The average age of the participants in the active group was 45.6 years versus 40.3 years for the placebo group. All subjects had Stage III-IV androgenetic alopecia. Eight subjects had excessive hair loss. The initial evaluation included health history, physical exam and evaluation of the alopecia condition. Any subjects with underlying diseases or subjects using systemic drugs (e.g. steroids, anti-hypertensives, cytotoxic compounds, vasodilators, anti-convulsant drugs, beta blockers, spironolactone, cimetidine, cyclosporine, anti-depressants) were excluded from the study. Informed consent was obtained from all patients before study entry. Each subject was tattooed with a permanent ink on their vertex area, creating a one centimeter triangle. The hair in the triangle was collected and the subjects entered an 8 week baseline period evaluation before beginning treatment.

During the study (including the baseline period of eight weeks) all the subjects washed their hair daily with HairPrime ® Shampoo. This was done to avoid the variable that the use of different shampoos would introduce.

Assessment Procedures:

Two of the commonly used methods of evaluating hair growth are: (1) counting the hair on the scalp in a marked area and (2) various photographic techniques. Both methods can have a large margin of error due to the difficulty in counting hair on the scalp and the possibility of photographing a bent hair shaft and counting it as two hairs. To avoid these problems a more accurate method for evaluating hair growth, based on a protocol developed by Price, was employed. The evaluation included: total hair count and terminal (non-vellus, melanized, mature) hair count.

Each subject was tattooed with permanent ink at three points on their vertex area creating a one centimeter triangle. After rinsing the hair at the permanent site with water and soap, the hair was washed with acetone to remove any debris that could change its weight. The hair from the triangle was collected using great care to harvest only within the marked area.

The hair collected was placed on white paper, counted and then divided into terminal hair (non-vellus, melanized, mature hair) and vellus hair. The terminal (non-vellus, melanized, mature) hairs were then counted.

Results:

Efficacy results demonstrate that HairPrime ® cream, used once daily, is much more effective than the placebo cream vehicle in the treatment of androgenetic alopecia. Table I compares the average percentage change from baseline of the total hair count and terminal (non-vellus) hair count between the HairPrime ® and the placebo-treated groups.

After 40 weeks, 70% of the subjects in the active group had greater than a 30% increase in total hair count, compared with 16% of the subjects in the placebo group. The average total hair count for HairPrime ® treated subjects increased by approximately 75%, compared to a 0% increase for the placebo treated subjects. 90% of the subjects in the active group had greater than a 30% increase in terminal (non-vellus, melanized, mature hair) hair counts, compared with 33% of the subjects in the placebo group. The average terminal hair (non-vellous, melanized, mature hair) count for HairPrime ® treated subjects increased by approximately170% over the same period, as compared to an approximately 34% increase for the placebo treated group.

Adverse Effects

No local irritation, sensitization or other averse effects were observed or reported in either the active or placebo groups.  

CONCLUSION:

HairPrime ® cream, a 7.5% standardized herbal extract preparation, is safe and effective in the treatment of androgenetic alopecia.

 

Success Stories

"A couple of years ago...I found out I was starting to get bald quite fast. After a couple of months [of using HairPrime] I noticed that I wasn't almost losing hair at all. Some time after this, I would say probably 6 or 7 months after I had started with the treatment I noticed I was regaining hair in the areas in which I had lost hair. After about a year I had regained quite a lot of hair in my former balding areas. Right now after about two years of having started with the treatment I believe I'm not losing hair any more and that the hair I regained remains very healthy. Needless is to say I'm very pleased with the results. Thanks to HairPrime I reversed my tendency to balding and I recovered my self esteem."

HM, Miami, FL

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"I felt as though I was condemned to being bald, and that would not change. My wife came home with this product and suggested that I try it. Over a period of several months, there began to appear new growth and she was very pleased which was really very satisfying to me. HairPrime really changed my life. It has made me a better person. I feel more confident in public. I began to see results at approximately three or four months. I would recommend HairPrime to anyone, especially someone who has a hair loss problem."

JV, San Rafael, CA

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"What an amazing product! Although I have only been using your products for three weeks, many many new hairs are already appearing over my three big bald areas. Especially being female, hair loss is in the very least a traumatic experience."

DB, Internet E-mail

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"Thank you for creating such an incredible product. It really does work! My hair was thinning on top in a hereditary balding pattern for five years before using your amazing HairPrime system. Now, after 7 months of using HairPrime, my hair is thicker and fuller. My receding hairline has been replaced with new hair. My stylist is very impressed with the results I'm getting and has never seen anything like it. Thanks again for making a product that really does what it says it does."

DK, Miami, FL

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"After just three months on HairPrime all of the gray hairs had turned back to their naturally dark color and the hair loss slowed considerably. These changes were fantastic and gave me renewed confidence. After being on HairPrime for almost a year now, I can honestly say that my hair is healthier and I have more of it."

KL, Underwood, WA

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"About three year ago I was complaining to the folks that cut my hair that my hair was falling out and I was losing it. They recommended HairPrime and I started using it right away. After about three months I noticed I had new hair growth. I feel great about HairPrime because it's working. The hair I got back from it was the same color and the same thickness as the hair that I'd lost."

DS, San Francisco, CA

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" I have been using HairPrime for exactly one year today and cannot thank you enough. Thinning hair over the top, and more so in the crown was quite apparent. I went on a rampage for 6 weeks determined to find a way to keep what I had and re-grow what I had lost. In March I was flipping through a magazine and saw an article on your product. I started your program in April. By July I had new tiny hairs visible, in September my panic subsided, by Christmas I was quite pleased - and now I'm absolutely thrilled! My hair looks great!"

BS, Cinnaminson, NJ

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"I have been a hairdresser all of my life. I have seen every hair product made for thinning hair. The only one that I have seen that really works is HairPrime. I have over 150 clients on HairPrime and every one of them is more than satisfied with their results."

CW, salon owner, Novato, CA

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"It is eight weeks tomorrow since I started using your Primer at the beginning for 15 days and then once every three days in combination with the HairPrime Cream. At the beginning of this week I began to see and feel more hair on my head and believe me, there was so little of it before this week that you almost felt nothing when you touched it. First it is growing daily (the length) you cannot miss it, but it has also thickened to an encouraging degree."

ZD, Atlanta, GA

FAQs

1. How does HairPrime ® work?

The HairPrime ® Program is aimed at providing the best overall environment for hair to grow. Even the shampoo is carefully formulated to avoid ingredients which are found in many other shampoos and which we have determined as harmful to the scalp and healthy hair growth. The active ingredients contained in HairPrime ® Herbal Lotion and Herbal Scalp Primer address the effects of environmental factors on the scalp and DHT (the main cause of male pattern baldness). If HairPrime's ingredients are effective, DHT doesn't have as much of an impact, and thus the follicle's potential for nurturing hair growth is improved . Through the regular use of HairPrime ® your body receives a constant supply of nutrients and healthy hair factors. We have found that most people need to use HairPrime ® for about 12 months before substantive results are experienced and confirmed. HairPrime ® aims to maintain a healthy environment for hair follicles and restore the normal growth cycles of hair to keep your hair growing longer and thicker until it matures (i.e. "The Conversion To Terminal Hair" presented at the American Academy of Dermatology Conference in New Orleans, March, 1999)

2. What does the HairPrime ® system consist of?

The HairPrime ® system consists of: The herbal shampoo, herbal lotion, scalp primer and herbal supplements. These four natural products have been purposefully developed to work together to create what we consider to be an optimum environment for hair to grow.

3. Who will benefit from the use of HairPrime ®?

People with: 1) androgenetic alopecia, more commonly known as "male pattern baldness" which affects both women and men; and 2) scalp inflammation due to environment or physiological responses (e.g. immune system response)

4. For what percent of people is the HairPrime ® Thinning Hair Program effective?

According to our clinical test results, 90% of the people that use the Hair Prime® thinning Hair Program will see results from the products. The results will vary according to the individual and their thinning hair condition. The people we tested are people with androgenetic alopecia, more commonly known as "male pattern baldness" which affects both men and women.

5. What kind of results can I expect to see and how soon will I see them?

Most individuals with actively thinning hair will notice an improvement in their thinning hair condition within 3-9 months of continuous, compliant use of the HairPrime ® Program products. Results generally continue to improve over time. It is recommended that you use HairPrime ® Program products for at least 12 months before deciding how well it works for you. After the second month of recommended use, the average person finding success using the HairPrime ® Program products experiences a significant reduction of daily hair loss. After 3-4 months, the vellus "baby" hair that were falling out prematurely in 3-5 weeks should start to convert yielding somewhat longer and fuller hair. Most of the subjects in our controlled study experience a significant conversion of "baby" hair to terminal/mature hair within 40 weeks. You may experience satisfactory results in less time or it may take as long as 12-18 months.

6. How long has the HairPrime ® Thinning Hair Program been available?

The HairPrime ® Program was developed by Universal Biologics, a biotech, Cosmeceutical Company founded in 1989. The program has been available in California since 1990. In 1991 it was introduced to the national and international markets. From 1990 to 1994 independent researches were conducted on the HairPrime ® formula. In 1995 the U.S. Patent Office granted Universal Biologics a patent on the HairPrime ® Cream and HairPrime ® Herbal Shampoo. In 1998, the HairPrime ® Program products were improved to include the HairPrime ® Herbal Scalp Primer.

7. The HairPrime ® Thinning Hair Program is such an important breakthrough for thinning hair. Why haven't I heard of it before?

Understanding the skepticism that many people have about thinning hair products, before going after the mass market, we have spent most of our time researching and testing the Hair Prime® Thinning Hair program to prove its effectiveness. Our marketing efforts have been limited to the direct sales through our 800 telephone number, the Internet, and a few exclusive catalogs such as SelfCare (a Northern California personal health care catalog). We have focused most of our marketing effort in ethical forums such as the American Academy of Dermatology (New Orleans 1995; Chicago, 1998; New Orleans, 1999), Hawaii Dermatology Seminar 1998), IBC Scientific Conference (Short Hills, NJ, 1999) and society of Chemists Annual Scientific Meeting (Chicago, 1999). It is our goal to reach the understanding and acceptance of the medical doctors and scientists to support our claims and efficiency so the public consumer may make a safer educated decision in whether to choose HairPrime ® over the other drug alternatives or other treatments. We do not feel that mass market retailing would work unless and until the consumer is fully and competently informed as to the proper use of HairPrime ® and the realistic expectations that may be achieved and gauged.

8. Why is HairPrime ® different from other natural hair products?

The main difference is in how each one of us substantiate our claims. When a company makes outrageous claims about the benefits of its products, a lot of attention should be paid on the research they are based on. Important questions must be asked, such as, was the research conducted in the U.S. or in some other country? Was it performed by independent Dermatologists? How long did the research take? Was the clinical test performed on real people, in a scientifically accepted random sampling? Were the tests just performed in vitro (i.e. in a test tube)? Has it been presented to ethical medical forums for scrutiny or published in a major medical journal? Reputed Doctors and Dermatologists, who are still currently practicing in the U.S., conducted the HairPrime's clinical double-blind (random with control and placebo subjects) study in the U.S. The study, which lasted 48 weeks, was presented at the 1995 Annual Conference of the American Academy of Dermatology and then published in the prestigious Journal of Dermatological Treatment in October 1996.

9. What is the purpose of the HairPrime ® Herbal & Vitamin Supplement?

The supplement works from the inside to strengthen the body's internal capacity to support thicker, healthier hair naturally. It contains 3 vitamins & minerals and 17 herbs that we deem beneficial for healthy hair growth. When taking the supplements, people often notice an increase in energy and vitality. Some of the herbs have recently been identified in research as strong antioxidants, while others have been long recognized in herbal medicine to contribute to a healthy environment for hair to grow.

10. Can I use another hair loss product with HairPrime ® Thinning Hair Program?

We advise that you use only one thinning hair product at a time. As far as we know, no one has done testing on the effectiveness or the effects of using multiple hair products simultaneously. However it is possible that multiple product use can work in treating thinning hair condition, but it may become quite expensive. If you prefer, Rogaine® can be used to initiate the growth of hair and HairPrime ® to nurture hair conversion. This approach may be logical but we suggest you consult your physician. Another thinning hair program that people like using is Propecia®. We see no reason, other than economic, why both Propecia® and HairPrime ® cannot be used at the same time.

11. Can women use HairPrime ®?

Most definitely, Yes. More important to note, it is the only safe product for women to use that indicates "5 alpha reductase inhibition like" activity and a conversion of vellus "baby" hair to terminal/mature hair. Propecia® , with Finasteride® , indicates the same, but women are warned against its use or coming in contact with the drug, especially those of reproductive age. Minoxidil® has been formulated and packaged for women, but there is no report of an ability to convert the vellus "baby" hair and has proven to be marginally effective for men and only the 2% Minoxidil® solution is marketed to women. The new extra strength 5% Minoxidil® is packaged to be sold to men only.

12. Will I need to use these products for life? 

After achieving the desired results, you can cut back on your use to 1-2 times a week to maintain what you have achieved [some people have reported an effective maintenance use of only 1-2 times per month], of course if you stop using HairPrime ® completely, nature will take its course.

13. Is there anything I could be doing that inhibits the effects of HairPrime ® Thinning Hair Program?

Factors including physical, physiological and chemical (e.g. synthetic ingredients) can reduce the results of HairPrime ® Thinning Hair Program. These factors can directly effect how the product performs for you. Changes in hormonal activity such as menopause or pregnancy, medications including those related to hormone changes, medical ailments, the use of hair products with occlusive ingredients such as heavy synthetic conditioners, hair sprays, and also high levels of vitamin A. Increasing stress levels can also be harmful. If you think that one of these things could be affecting the product for you, consult customer support.

14. I lost my hair many years ago, will HairPrime ® Work for me?

Yes, men and women in all stages of thinning, regardless of your age or how long it has been since you first started thinning can use HairPrime ® Thinning Hair Program. However, if you are completely bald on top, it may not be cost beneficial for example if you have 100 follicles with hair that convert and that number doubles, a 100% increase will still only be 200 hairs… statistically significant, but aesthetically still an appearance of baldness. The sooner you start treating your hair loss the better chance you have at saving what you have and helping those surviving hair follicles to convert vellus baby hair to terminal hair by extending the growth cycle.

15. I typically wash my hair once a week; will this program still be useful?

We recommend that people wash daily to keep the scalp clean and at least every other day to allow the active Herbal Lotion to be more effective. If you do not wash your hair at least every other day, we definitely recommend using HairPrime ® scalp primer to remove the build-up of daily dirt and oils that creates residue while delivering a supplement of herbal extracts to support the herbal lotion.

16. My hair feels oily when I use the HairPrime ® Lotion, is this normal?

Yes, your hair may feel conditioned, oily or weighed down from using the HairPrime ® Herbal Lotion (or Cream) depending on the condition (e.g. dry, oily, very thin hair, straight hair, frizzy hair etc.) However, many people apply too much. Remember, the lotion is applied on the scalp not the hair. The amount in each bottle of lotion is measured to last the person two months. Over-applying the product will not make the product work faster; you are only wasting the excess. If you don't like the way it makes your hair look, we advise applying the lotion/cream at night as directed and rinsing it off in the morning.
 

17. Does the shampoo have an effect on the thinning hair condition?

Our shampoo is primarily a mild cleanser and will not irritate the scalp. It has a high concentration of herbal extracts and leaves the hair feeling fresh and clean. It is designed to cleanse and prepare the scalp to support the effectiveness of the Herbal Lotion.

18. Can I use another Shampoo instead of HairPrime's?

If you do not like our shampoo, we suggest you choose a shampoo that is similar to HairPrime's. Many shampoos have conditioners and occlusive ingredients that may diminish the effect of the Herbal Lotion. Some conditioners (e.g. -methicones) may make the hair look or feel silky, but they also block the effects of the Herbal Lotion. Therefore, we suggest that you use HairPrime ® Shampoo to cleanse your scalp just before you apply the Herbal Lotion. On the day(s) you are not applying the Lotion, you may use a shampoo of your choice. However, if you notice that you loose more hair by using another shampoo, we recommend you desist and call our customer support.

19. I am over thirty years old and I work full time. Lately, I have been under a lot of stress and I have noticed increasing thinning, what can I do?

It is very common to experience thinning due to stress. Stress depletes the body of important nutrients that are needed to maintain health. We recommend using the HairPrime ® Program for thinning hair. The HairPrime ® Program is particularly effective because it is comprised of herbal products that create a healthy environment for hair growth.

20. My doctor has me on all kinds of medications and I wonder if HairPrime ® supplements will interfere with them?

HairPrime ® supplements are natural and gently effective in increasing vitality and an overall sense of well being. The HairPrime ® supplements are not likely to interfere with any prescription medicines, but only a physician can be certain, based on one's health history and physiological reaction to the ingredients (e.g. some people have an adverse reaction to something as common as the mineral, Zinc.) So, when in doubt, either consult a physician or refrain from taking the supplements.

21. Are there any differences expected for women since the official results are based on experience with men?

The women who are currently using HairPrime ® have written some of our strongest testimonials and have experienced more favorable results of all our customers. HairPrime ® has been reported to be effective in treating Androgenetic Alopecia ("male pattern baldness") which affects women, too. The differences between men and women regarding Androgenetic Alopecia are the higher levels of 5 alpha reductase (the enzyme required to convert testosterone to DHT, the culprit behind the problem) and the quantitative differences in the two forms of the enzyme as well as the androgen receptors. Thus, accounting for the milder expression of hereditary hair thinning in women.

22. Why didn't the clinical trials include a larger sample of people and why has it not been tested on women?

First of all, there is no statistical significance in a larger sample, so long as the sample is adequate and the protocol is truly random and blind. A few women were tested in the pilot studies, but we were not successful in convincing women to participate in a study that required tattooing the scalp, periodically cutting the hair in that area at scalp level and staying with this routine for 40 weeks. Because of the economics and effort required to convince a statistically significant sample (at least 21) to participate in such a study, we have tabled our test on women for the future.

HOW TO USE

EVERY OTHER DAY FOR THE FIRST 6 TO 12 MONTHS

TWO HOURS BEFORE GOING TO SLEEP, THE FOLLOWING STEPS

Step 1

CLEANSE SCALP USING HAIRPRIME HERBAL SHAMPOO. IF YOU PREFER ANOTHER SHAMPOO, BE SURE THAT IT DOES NOT CONTAIN INGREDIENTS THAT ARE OCCLUSIVE (E.G. DIMETHICONE or other silicon type ingredient, HEAVY CONDITIONERS). SOME INGREDIENTS FOUND IN OTHER SHAMPOOS MAY ALTER THE EFFECTIVENESS OF THE ACTIVE INGREDIENTS IN THE HERBAL LOTION.

Step 2

WHILE HAIR IS STILL DAMP, PART YOUR HAIR STARTING ON ONE SIDE OF THE TOP OF YOUR SCALP. ALONG THE PART, SQUEEZE A THIN LINE OF THE HAIRPRIME HERBAL LOTION AND LIGHTLY PRESS OR RUB INTO THE SCALP WITH FINGER. MOVING OVER 1 ¼ INCH, REPEAT PARTING THE HAIR AND APPLYING THE LOTION AND CONTINUE UNTIL YOU REACH THE OTHER SIDE OF THE TOP OF YOUR SCALP. IF YOU MUST STYLE, COMB GENTLY WITH A WIDE TOOTH COMB OR BRUSH. LET DRY NATURALLY...DO NOT BLOW DRY! AFTER AT LEAST 8-10 HOURS OF BEING APPLIED, WAKE UP AND RINSE HAIR WITH WARM WATER OR WASH YOUR HAIR. GENTLY TOWEL DRY. PLEASE NOTE THAT EACH 2oz BOTTLE IS DESIGNED AND MEASURED TO LAST THE AVERAGE USER 2 MONTHS, IF THE PRODUCT IS DEPLETING FASTER, THEN YOU ARE MOST PROBABLY OVER APPLYING OR NOT LIMITING THE APPLICATION TO THE SCALP (i.e. applying to the hair or allowing the hair to absorb most of the lotion is a waste, so try to apply strictly to the scalp areas to be treated).

Step 3

APPLY HAIRPRIME SCALP PRIMER BY SQUEEZING 5 TO 8 DROPS IN DIFFERENT AREAS ON TOP OF THE SCALP (EMPHASIZING THE DESIRED AREAS TO BE TREATED AND SPREAD BY ROTATING OR ROLLING YOUR HEAD AROUND. ALLOW TO DRY AND BE ABSORBED FOR APPROXIMATELY 1 MINUTE, THEN STYLE AS YOU DESIRE . DO NOT APPLY SCALP PRIMER WITHIN 3 HOURS OF APPLYING THE HERBAL LOTION.

EVERY DAY, TAKE TWO TABLETS OF THE HAIRPRIME HERBAL & VITAMIN SUPPLEMENT. CONTAINS ZINC, BIOTIN & PANTOTHENIC ACID FOR THE HAIR AND NATURAL HERBS THAT HAVE BEEN LONG RECOGNIZED IN HERBAL MEDICINE TO BE BENEFICIAL TO HAIR.