Title

Transcutaneous absorption of ketoconazole in infant after application of Ketoderm

Original Title

Passage transcutané du kétoconazole chez le nourrisson après application de Ketoderm.

Author

Levron JC; Taieb A

Address

Laboratoire de Pharmacocinétique, Laboratoires Janssen, Boulogne.

Source

Therapie, 46: 1, 1991 Jan-Feb, 29-31

Abstract

The percutaneous absorption of ketoconazole was studied in 7 infants (1 to 5 month of age) with extensive seborrhoeic dermatitis (greater than 50% of the surface area), after application of a 2% ketoconazole cream (Ketoderm). The plasma concentrations of ketoconazole were measured by HPLC at the first, 5^th and 10^th day of the treatment. Despite the large surface involved, plasma levels ranging, from 0.018 to 0.133 micrograms/ml were measured. These values are low, as compared with the concentrations observed following oral administration (4 to 9 micrograms/ml), and suggest that the occurrence of systemic dose-dependent side effects is very unlikely. A careful monitoring of prescription remains however necessary.

Language of Publication

French

Unique Identifier

9121316