Title
Local inhibition of sebaceous gland growth by topically applied RU 58841.
Author
Matias JR, Gaillard M
Address
Nova Biosciences, Norrie Point Research Station, Staatsburg, New York 12553, USA.
Source
Ann N Y Acad Sci, 761:1995 Jun 12, 56-65
Abstract
The biological activity of a series of nonsteroidal, pure androgen receptor inhibitors was
compared using the Syrian hamster ear skin sebaceous gland model. RU 58841, RU 56187, RU
38882 and cyproterone acetate were applied topically for 4 weeks on the ventral ear pinna
of sexually mature male Syrian hamsters. Their order of efficacy was as follows: RU 58841
> RU 56187 > RU 38882 > cyproterone acetate. Maximal reduction of 60% in the size
of the sebaceous glands was observed in hamsters treated with RU 58841 at a dose of 10
micrograms per day. This degree of inhibition occurred without any systemic side effects
as shown by the absence of inhibition
on the contralateral untreated ear pinna. Longer treatment did not produce greater
inhibition since extending the treatment period from 4 weeks to 12 weeks showed similar
data. The effect of RU 58841 was reversible since the inhibited sebaceous glands returned
to normal size within 4 weeks after the cessation of the topical applications. The potent
localized inhibition of sebaceous glands by RU 58841
demonstrates the excellent potential of this compound as a topical drug for the treatment
of acne and other androgen-mediated disorders.
Language of Publication
English
Unique Identifier
95351703